Development of a reliable non-union model in mice.

@article{Garcia2008DevelopmentOA,
  title={Development of a reliable non-union model in mice.},
  author={Patric Garcia and Joerg H. Holstein and Sabrina Maier and Hagen Schauml{\"o}ffel and Fuad Al-Marrawi and Matthias Hannig and Tim Pohlemann and Michael Dieter Menger},
  journal={The Journal of surgical research},
  year={2008},
  volume={147 1},
  pages={
          84-91
        }
}
BACKGROUND Despite the growing knowledge of the mechanisms of fracture healing, non-unions remain a substantial clinical problem. There is increasing interest in murine fracture models because they would allow studying molecular mechanisms of healing with the help of specific antibodies and gene-targeted animals. However, until now it has not been possible to reproducibly create non-unions in mice. Thus, the aim of this study was to develop a reliable non-union model in mice. METHODS After… CONTINUE READING

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