Development of a recombinant yellow fever vector expressing a HIV clade C founder envelope gp120.

@article{Yu2017DevelopmentOA,
  title={Development of a recombinant yellow fever vector expressing a HIV clade C founder envelope gp120.},
  author={J Yu and H. X. Liao and Jamie Pritchett and Cindy M Bowman and Callie Vivian and Robert J. Parks and Shi-Mao Xia and Melissa Cooper and Wilton B Williams and Mattia Bonsignori and Steven G Reed and Meng Chen and Nathan A. Vandergrift and Charles M. Rice and Barton F Haynes},
  journal={Journal of virological methods},
  year={2017},
  volume={249},
  pages={85-93}
}
Development of a HIV-1 vaccine is a major global priority. The yellow fever virus (YFV) attenuated vaccine 17D is among the most effective of currently used vaccines. However, the stability of the YFV17D vector when carrying non-flavivirus genes has been problematic. We have constructed and expressed HIV-1 Env in YFV17D with either single transmembrane (STM) or double transmembrane (DTM) YFV E protein domains for the development of anti-HIV antibodies. Here we describe modifications of the… CONTINUE READING