Development of a recombinant hCG-specific single chain immunotoxin cytotoxic to hCG expressing cancer cells.


A large number of cancers express human chorionic gonadotropin (hCG) or its subunits ectopically. Patients harboring such cancers have poor prognosis and adverse survival. PiPP is a monoclonal antibody of high affinity and specificity for hCGβ/hCG. Work was carried out to develop a PiPP based recombinant immunotoxin for the immunotherapy of hCG expressing… (More)
DOI: 10.1016/j.pep.2014.10.008


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