Development of a quinoxaline-based fluorescent probe for quantitative estimation of protein binding site polarity.

@article{Kudo2011DevelopmentOA,
  title={Development of a quinoxaline-based fluorescent probe for quantitative estimation of protein binding site polarity.},
  author={K. Kudo and A. Momotake and Yoko Kanna and Y. Nishimura and T. Arai},
  journal={Chemical communications},
  year={2011},
  volume={47 13},
  pages={
          3867-9
        }
}
The compound 2-[(1E)-2-(1H-pyrrol-2-yl)ethenyl]-quinoxaline (PQX) is a promising fluorescent chromophore for the estimation of protein binding site polarity, due to its full-color solvatochromic fluorescence. A linear relationship was obtained between the peak emission wavenumber and E(T)(N) (normalized solvent polarity). The BSA binding site polarity was estimated from the solvatochromic plot. 
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