Development of a psilocin immunoassay for serum and blood samples

  title={Development of a psilocin immunoassay for serum and blood samples},
  author={C. Albers and H. K{\"o}hler and M. Lehr and B. Brinkmann and J. Beike},
  journal={International Journal of Legal Medicine},
  • C. Albers, H. Köhler, +2 authors J. Beike
  • Published 2004
  • Chemistry, Medicine
  • International Journal of Legal Medicine
  • After the immunisation of rabbits with a psilocin-specific immunogen, polyclonal antisera were obtained. With these antisera a competitive, heterogeneous radioimmunoassay for the detection of psilocin was developed. As tracer a derivative of psilocin was synthesised, which contained a tritiated CH3 group. The antisera showed a specific reaction with psilocin. The cross-reactivity of structurally related endogenous substances like serotonin, tryptophan and tyrosine was below 0.01%. Also common… CONTINUE READING
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