Development of a predictive limited sampling strategy for estimation of mycophenolic acid area under the concentration time curve in patients receiving concomitant sirolimus or cyclosporine.

@article{Figurski2008DevelopmentOA,
  title={Development of a predictive limited sampling strategy for estimation of mycophenolic acid area under the concentration time curve in patients receiving concomitant sirolimus or cyclosporine.},
  author={Michal J Figurski and Artur Nawrocki and Mark D. Pescovitz and Rene M Bouw and Leslie M. Shaw},
  journal={Therapeutic drug monitoring},
  year={2008},
  volume={30 4},
  pages={445-55}
}
Limited sampling strategies for estimation of the area under the concentration time curve (AUC) for mycophenolic acid (MPA) co-administered with sirolimus (SRL) have not been previously evaluated. The authors developed and validated 68 regression models for estimation of MPA AUC for two groups of patients, one with concomitant SRL (n = 24) and the second with concomitant cyclosporine (n=14), using various combinations of time points between 0 and 4 hours after drug administration. To provide as… CONTINUE READING