Development of a pre-glycoengineered CHO-K1 host cell line for the expression of antibodies with enhanced Fc mediated effector function

@inproceedings{Popp2018DevelopmentOA,
  title={Development of a pre-glycoengineered CHO-K1 host cell line for the expression of antibodies with enhanced Fc mediated effector function},
  author={Oliver Popp and Samuel Moser and J{\"o}rg Zielonka and Petra R{\"u}ger and Silke Hansen and Oliver Pl{\"o}ttner},
  booktitle={mAbs},
  year={2018}
}
Novel biotherapeutic glycoproteins, like recombinant monoclonal antibodies (mAbs) are widely used for the treatment of numerous diseases. The N-glycans attached to the constant region of an antibody have been demonstrated to be crucial for the biological efficacy. Even minor modifications of the N-glycan structure can dictate the potency of IgG effector functions such as the antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Here, we present the… CONTINUE READING

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