Development of a porcine model of type 1 diabetes by total pancreatectomy and establishment of a glucose tolerance evaluation method.

@article{Kobayashi2004DevelopmentOA,
  title={Development of a porcine model of type 1 diabetes by total pancreatectomy and establishment of a glucose tolerance evaluation method.},
  author={Kazuya Kobayashi and Naoya Kobayashi and Teru Okitsu and Chen Yong and Takuya Fukazawa and Hideaki Ikeda and Yoshikazu Kosaka and Michiki Narushima and Takashi Arata and Noriaki Tanaka},
  journal={Artificial organs},
  year={2004},
  volume={28 11},
  pages={1035-42}
}
PURPOSE To develop and evaluate the efficacy of diabetes-targeted cell therapies in humans, a reliable model in larger animals is highly desirable. This article reports the surgical technique of total pancreatectomy in pigs and the biochemical analysis of the characteristics of totally pancreatectomized pigs. METHODS Surgical total pancreatectomy was conducted in 23 pigs. Blood glucose, insulin, biochemistries, activity index, and intravenous glucose tolerance test (IVGTT) were examined to… CONTINUE READING

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