Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A.

@article{Yang2015DevelopmentOA,
  title={Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A.},
  author={Xiaoxia Yang and Daniel R. Doerge and Justin G. Teeguarden and Jeffrey Fisher},
  journal={Toxicology and applied pharmacology},
  year={2015},
  volume={289 3},
  pages={
          442-56
        }
}
A previously developed physiologically based pharmacokinetic (PBPK) model for bisphenol A (BPA) in adult rhesus monkeys was modified to characterize the pharmacokinetics of BPA and its phase II conjugates in adult humans following oral ingestion. Coupled with in vitro studies on BPA metabolism in the liver and the small intestine, the PBPK model was parameterized using oral pharmacokinetic data with deuterated-BPA (d6-BPA) delivered in cookies to adult humans after overnight fasting. The… CONTINUE READING

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