Development of a physiologically based pharmacokinetic model for 2,4-dichlorophenoxyacetic acid dosimetry in discrete areas of the rabbit brain.

@article{Kim1995DevelopmentOA,
  title={Development of a physiologically based pharmacokinetic model for 2,4-dichlorophenoxyacetic acid dosimetry in discrete areas of the rabbit brain.},
  author={Chung S Kim and William Slikker and Zbigniew Binienda and Michael L. Gargas and Melvin E. Andersen},
  journal={Neurotoxicology and teratology},
  year={1995},
  volume={17 2},
  pages={111-20}
}
A basic PBPK model for the dosimetry of organic acids in discrete areas of the brain was constructed using 2,4-D as a model compound. The PBPK model describes distribution of 2,4-D throughout the body and within discrete areas of the brain. The brain compartments in the model were the hypothalamus, caudate nucleus, hippocampus, forebrain, brainstem, and… CONTINUE READING