Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases.

@article{Atkinson2010DevelopmentOA,
  title={Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases.},
  author={J. Atkinson and R. Falconer and D. Edwards and C. Pennington and C. Siller and S. Shnyder and M. Bibby and L. Patterson and P. Loadman and J. Gill},
  journal={Cancer research},
  year={2010},
  volume={70 17},
  pages={
          6902-12
        }
}
Vascular disrupting agents (VDA) offer a strategy to starve solid tumors of nutrients and oxygen concomitant with tumor shrinkage. Several VDAs have progressed into early clinical trials, but their therapeutic value seems to be compromised by systemic toxicity. In this report, we describe the design and characterization of a novel VDA, ICT2588, that is nontoxic until activated specifically in the tumor by membrane-type 1 matrix metalloproteinase (MT1-MMP). HT1080 cancer cells expressing MT1-MMP… Expand
41 Citations
A Novel Theranostic Strategy for MMP-14–Expressing Glioblastomas Impacts Survival
Antiangiogenesis enhances intratumoral drug retention.
Optimization of a MT1-MMP-targeting Peptide and Its Application in Near-infrared Fluorescence Tumor Imaging
  • Li Ren, Ye Wang, +7 authors X. Fang
  • Chemistry, Medicine
  • Scientific Reports
  • 2018
Quantum dots tethered membrane type 3 matrix metalloproteinase-targeting peptide for tumor optical imaging.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 46 REFERENCES
Microtubule depolymerizing vascular disrupting agents: novel therapeutic agents for oncology and other pathologies
Tumor targeting with a selective gelatinase inhibitor
Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion.
  • M. Seiki
  • Chemistry, Medicine
  • Cancer letters
  • 2003
MT1-MMP: Universal or particular player in angiogenesis?
Tumour endoproteases: the cutting edge of cancer drug delivery?
Matrix metalloproteinases and tumor metastasis
...
1
2
3
4
5
...