Development of a novel trans-lentiviral vector that affords predictable safety.

  title={Development of a novel trans-lentiviral vector that affords predictable safety.},
  author={Xue-ling Wu and John K. Wakefield and Honglei Liu and Haixia Xiao and Robert Kralovics and Josef T Prchal and John C Kappes},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={2 1},
Lentiviral vectors derived from human immunodeficiency virus type 1 (HIV-1) hold great promise for gene therapy. However, the possibility of generating replication-competent retrovirus (RCR) through genetic recombination raises concerns for safety. Here we describe a novel HIV-based packaging system (trans-lentiviral) that splits gag/gag-pol into two parts: One that expresses gag/gag-pro and another that expresses reverse transcriptase and integrase as fusion partners of viral protein R (Vpr… CONTINUE READING


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