Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid

Abstract

For successful cancer gene therapy via intravenous (i.v.) administration, it is essential to optimize the stability of carriers in the systemic circulation and the cellular association after the accumulation of the carrier in tumor tissue. However, a dilemma exists regarding the use of poly(ethylene glycol) (PEG), which is useful for conferring stability in… (More)
DOI: 10.1038/sj.gt.3302843

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Cite this paper

@article{Hatakeyama2007DevelopmentOA, title={Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid}, author={Hitoshi Hatakeyama and Harukuni Akita and Kentaro Kogure and Minoru Oishi and Yasuko Nagasaki and Yasunori Kihira and Munehisa Ueno and Hiroshi Kobayashi and Hideaki Kikuchi and Hideyoshi Harashima}, journal={Gene Therapy}, year={2007}, volume={14}, pages={68-77} }