Development of a novel sustained release formulation of recombinant human growth hormone using sodium hyaluronate microparticles.

@article{Kim2005DevelopmentOA,
  title={Development of a novel sustained release formulation of recombinant human growth hormone using sodium hyaluronate microparticles.},
  author={Sun Jin Kim and Sei Kwang Hahn and Myung Jin Kim and Duk Hee Kim and Young Phil Lee},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2005},
  volume={104 2},
  pages={323-35}
}
A novel sustained release formulation of recombinant human growth hormone (SR-rhGH) was developed as a once-a-week injection formulation using sodium hyaluronate. SR-rhGH was produced in the form of solid microparticles by spray drying technology. A single administration of a prototype formulation of SR-rhGH with a ratio of hGH:HA=1:1 to cynomolgus monkeys through a fine 26-gauge needle induced continuous elevation of serum IGF-I level for 6 days demonstrating the bioactivity of hGH released… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Similar Papers

Loading similar papers…