Development of a novel small antibody that retains specificity for tumor targeting

@article{Zhen2009DevelopmentOA,
  title={Development of a novel small antibody that retains specificity for tumor targeting},
  author={Zi-Peng Zhen and Jie Zhang and Si-yuan Zhang},
  journal={Journal of Experimental & Clinical Cancer Research : CR},
  year={2009},
  volume={28},
  pages={59 - 59}
}
BACKGROUND For the targeted therapy of solid tumor mediated by monoclonal antibody (mAb), there have different models of rebuilding small antibodies originated from native ones. Almost all natural antibody molecules have the similar structure and conformation, but those rebuilt small antibodies cannot completely keep the original traits of parental antibodies, especially the reduced specificity, which gravely influences the efficacy of small antibodies. METHODS In this study, authors… CONTINUE READING
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