Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators.

@article{Shirasaka1996DevelopmentOA,
  title={Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators.},
  author={Tetsuhiko Shirasaka and Y Shimamato and Hideyuki Ohshimo and Motonori Yamaguchi and Tsuyoshi Kat{\^o} and Kazuhiko Yonekura and Masakazu Fukushima},
  journal={Anti-cancer drugs},
  year={1996},
  volume={7 5},
  pages={
          548-57
        }
}
We have focused our attention on the development of a novel form of a tegafur-based [FT; a prodrug of 5-fluorouracil (5-FU)] antitumor agent. We have used two biochemical and pharmacological modulators of 5-FU to improve its overall activity. To potentiate the antitumor activity of FT, 5-chloro-2,4-dihydroxypyridine (CDHP) was used as a potent reversible inhibitor of 5-FU degradation. The reduction of gastrointestinal (GI) toxicity, induced in the host by 5-FU, was modulated by potassium… CONTINUE READING
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