Development of a novel efficient fluorescence-based plaque reduction microneutralization assay for measles virus immunity.

@article{Haralambieva2008DevelopmentOA,
  title={Development of a novel efficient fluorescence-based plaque reduction microneutralization assay for measles virus immunity.},
  author={Iana H. Haralambieva and Inna G. Ovsyannikova and Robert A Vierkant and Gregory A. Poland},
  journal={Clinical and vaccine immunology : CVI},
  year={2008},
  volume={15 7},
  pages={1054-9}
}
The measurement of functional measles virus-specific neutralizing antibodies is of considerable interest for vaccine-related research. In this study, we developed and standardized a simple, rapid, highly sensitive, and reproducible fluorescence-based plaque reduction microneutralization (PRMN) assay with visual and automated readout, using a recombinant measles virus engineered to express enhanced green fluorescent protein. The assay is performed in micro format, requires less time to complete… CONTINUE READING
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