Development of a novel bioreactor for the mechanical loading of tissue-engineered heart muscle.

@article{Birla2007DevelopmentOA,
  title={Development of a novel bioreactor for the mechanical loading of tissue-engineered heart muscle.},
  author={Ravi K. Birla and Yong Can Huang and Robert Anthony Gamboa Dennis},
  journal={Tissue engineering},
  year={2007},
  volume={13 9},
  pages={
          2239-48
        }
}
OBJECTIVE In this study, we describe a novel bioreactor system to deliver controlled stretch protocols to bioengineered heart muscle (BEHM) constructs. Our primary objective was to evaluate the effect of mechanical stretch on the contractile properties of three-dimensional cardiac constructs in vitro. METHODS BEHMs were formed by culturing primary neonatal cardiac myocytes in a fibrin gel using a method previously developed in our laboratory. A custom bioreactor system was designed using… CONTINUE READING

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