Development of a non-viral gene delivery vector based on the dynein light chain Rp3 and the TAT peptide.

@article{Favaro2014DevelopmentOA,
  title={Development of a non-viral gene delivery vector based on the dynein light chain Rp3 and the TAT peptide.},
  author={Marianna Teixeira de Pinho Favaro and Marcelo Augusto Szymanski de Toledo and Rafael F. Alves and Clelton Aparecido Dos Santos and Lilian Luzia Beloti and Richard Janissen and Lucimara Gaziola de la Torre and Anete P Souza and Adriano Rodrigues Azzoni},
  journal={Journal of biotechnology},
  year={2014},
  volume={173},
  pages={10-8}
}
Gene therapy and DNA vaccination trials are limited by the lack of gene delivery vectors that combine efficiency and safety. Hence, the development of modular recombinant proteins able to mimic mechanisms used by viruses for intracellular trafficking and nuclear delivery is an important strategy. We designed a modular protein (named T-Rp3) composed of the… CONTINUE READING