Corpus ID: 94040351

Development of a non-steroidal aromatase inhibitor-based protocol for the control of ovarian function using a bovine model

@inproceedings{Yapura2013DevelopmentOA,
  title={Development of a non-steroidal aromatase inhibitor-based protocol for the control of ovarian function using a bovine model},
  author={M. J. Yapura},
  year={2013}
}
............................................................................................................. ii ACKNOWLEDGEMENTS ....................................................................................... v DEDICATION ........................................................................................................ vii TABLE OF CONTENTS ....................................................................................... viii LIST OF TABLES… Expand

References

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TLDR
Treatment with letrozole increased endogenous concentrations of LH and extended the lifespan of the dominant follicle, which delayed the next FSH surge and subsequent follicular wave emergence, and continues to have potential as a non-steroidal treatment for controlling ovarian function in cattle. Expand
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Letrozole is therefore a highly effective inhibitor of aromatase, causing near complete inhibition of the enzyme in peripheral tissues at the doses investigated, and the falls in estrogen levels were greater than those seen with earlier generation aromat enzyme inhibitors. Expand
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YM511 significantly inhibited testosterone-stimulated transcriptional activation of estrogen-responsive element (ERE) in MCF-7 cells transfected transiently with ERE-luciferase reporter plasmid, suggesting that the inhibition by YM511 of cell proliferation of MCf-7 is attributed to the decreased production of estrogen due to the inhibition of aromatase activity. Expand
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TLDR
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TLDR
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Oestrogen production in bone appears to be as vital for the maintenance of bone mineralisation and the prevention of osteoporosis in men as it is in women, and local production of oestrogens, both intratesticular and extragonadal, is of physiological significance throughout adult life. Expand
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