Development of a nitric oxide induction assay as a potential replacement for the intracerebral mouse protection test for potency assay of pertussis whole cell vaccines.

@article{Canthaboo1999DevelopmentOA,
  title={Development of a nitric oxide induction assay as a potential replacement for the intracerebral mouse protection test for potency assay of pertussis whole cell vaccines.},
  author={Catpagavalli Canthaboo and Dorothy K-L Xing and Michael J. Corbel},
  journal={Developments in biological standardization},
  year={1999},
  volume={101},
  pages={95-103}
}
The intracerebral mouse protection test (Kendrick test) for the potency assay of pertussis vaccines is a complex and time consuming in vivo test which has a significant intra- and interlaboratory variation. Thus, there is a pressing need to develop a replacement for the Kendrick test. There is now convincing evidence to suggest that Bordetella pertussis can… CONTINUE READING