Development of a new purified vero cell rabies vaccine (Rabivax-S) at the serum institute of India Pvt Ltd

  title={Development of a new purified vero cell rabies vaccine (Rabivax-S) at the serum institute of India Pvt Ltd},
  author={Prasad S. Kulkarni and Ashish Sahai and Bhagwat K Gunale and Rajeev M. Dhere},
  journal={Expert Review of Vaccines},
  pages={303 - 311}
ABSTRACT Introduction: Rabies is a 100% fatal disease with significant disease burden in Asia and Africa but preventable with vaccines and immunoglobulins. There are very few WHO prequalified cell culture derived rabies vaccines available globally for use in humans. We have developed a new purified vero cell rabies vaccine (Rabivax-S) to meet this demand. Areas covered: In this review, we have described the detailed manufacturing process of Rabivax-S and summary of preclinical and clinical… 

History of Rabies and Rabies Vaccines

Improvements likely to cause paradigm shift include products based on virus-like particles, obviating the need for a high containment facility; sparing usage of antigens using new adjuvants; delivery using novel systems; and direct inoculation of potent vaccines without the need of rabies immune globulin (RIG).

Rabies and Rabies Vaccines

The basis of rabies classification, epidemiology and pathogenesis is reviewed highlighting areas for potential improvement in the authors' understanding of this important group of viruses.

An Evaluation of Different Types of Peptone as Partial Substitutes for Animal-derived Serum in Vero Cell Culture

It is shown that plant-based peptones could represent promising options for the successful formulation of serum-reduced cell culture media for vaccine production, in view of the urgent need for SARS-CoV-2 virus production for certain types of vaccine.

Differential susceptibility & replication potential of Vero E6, BHK-21, RD, A-549, C6/36 cells & Aedes aegypti mosquitoes to three strains of chikungunya virus

C6/36 cell line was found to be the most sensitive and high yielding for CHIKV irrespective of lineages while Vero E6 and BHK-21 cell lines yielded high titres and may find application for vaccine/diagnostic development.

Effect of change in cell substrate on the critical quality attributes of L-Zagreb Mumps vaccine manufactured using parallel plate bioreactor.

  • R. MuleyR. Dhere
  • Biology
    Biologicals : journal of the International Association of Biological Standardization
  • 2020

Influence of Protective Media Composition and Storage Temperatures on Preservation of Rabies Virus Vaccine Strain L. Pasteur

Here, we studied the effect of protective media supplemented with sucrose, glycerol, and maltose on the preservation of the rabies virus vaccine strain L. Pasteur during storage at various



An immunogenicity, safety and post-marketing surveillance of a novel adsorbed human diploid cell rabies vaccine (Rabivax®) in Indian subjects

Rabivax (adsorbed) is an immunogenic, safe, and efficacious vaccine for rabies prophylaxis in humans and shows better rabies virus neutralizing antibody (RVNA) response on day 90 than MIRV.

Intra-dermal administration of rabies vaccines in developing countries: At an affordable cost

The Intradermal Rabies Vaccine (IDRV) was first started in Thailand in 1984 and in 1992, World Health Organization approved it for use in developing countries which face a shortage of rabies vaccine due to paucity of funds.

Immunogenicity of Two Modern Tissue Culture Rabies Vaccines in Pre-Exposure Prophylaxis

The IndianHDC vaccine compares well with the CEC vaccine in terms of immunogenicity, and since the new HDC vaccine has a comparable cost to the C EC vaccine, it may be possible to use it in large-scale vaccinations.

Development in Immunoprophylaxis against Rabies for Animals and Humans

Rabies is a fatal neurological disease and a persistent global problem. It is spread primarily by domestic dogs but other canid, viverrid (skunks and raccoons) and chiropteran species are considered

Antibody response of patients after postexposure rabies vaccination with small intradermal doses of purified chick embryo cell vaccine or purified Vero cell rabies vaccine.

PCECV is a safe and highly immunogenic vaccine for postexposure rabies vaccination when administered intradermally in 0.1-ml doses using the two-site method recommended by WHO.

Evaluation of Cost-Effective Strategies for Rabies Post-Exposure Vaccination in Low-Income Countries

It is concluded that a universal switch to ID delivery would improve the affordability and accessibility of PEP for bite victims, leading to a likely reduction in human rabies deaths, as well as being economical for healthcare providers.

Assessing the burden of human rabies in India: results of a national multi-center epidemiological survey.

  • M. SudarshanS. Madhusudana Gangaboraiah
  • Medicine
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
  • 2007