Development of a new method for synthesis of biologically active compounds with the use of the typed strainStreptomyces werraensis ATCC 1365

  title={Development of a new method for synthesis of biologically active compounds with the use of the typed strainStreptomyces werraensis ATCC 1365},
  author={E. P. Rusanova and Tatiana Alekhova and Galina B. Fedorova and Genrikh S. Katrukha},
  journal={Applied Biochemistry and Microbiology},
The regulatory function of a DNA fragment responsible for actinomycin resistance in the typed strainStreptomyces werraensis ATCC 1365, which produces a macrotetrolide antibiotic, was studied. Metabolic changes made this strain capable of producing an antibiotic complex, which comprises four biologically active compounds absent from the parent culture. 
Antitumor activity of Actinobacteria isolated in marine sediment from Todos Santos Bay, Baja California, Mexico
Se realizo el estudio de la bioactividad de las Actinobacterias cultivables a partir de sedimento marino de la Bahia de Todos Santos, Mexico, y se identificaron mediante las secuencias del gen 16S


Genetics and biochemistry of antibiotic production.
Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes
It is shown that cloned DNA coding for one synthase might be used as a hybridization probe for the isolation of others and that this is indeed possible and valuable in giving access to groups of linked biosynthetic genes.
Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2)
Results indicate that the onset and extent of secondary metabolism in Streptomyces spp.
The Leeuwenhoek Lecture, 1987 - Towards an understanding of gene switching in Streptomyces, the basis of sporulation and antibiotic production
  • D. Hopwood
  • Biology
    Proceedings of the Royal Society of London. Series B. Biological Sciences
  • 1988
Genetic analysis clearly reveals a regulatory cascade operating at several levels in a ‘physiological’ branch of the differentiation control system, and it is attractive to speculate that the latter play a dual role: protecting the organism from self-destruction by its own potentially lethal product, and ensuring that resistance is established before any antibiotic is made.
Syntheses and antibacterial activities of penicillins from (+)- and ( )- -amino-4-isothiazolylacetic acids.
  • R. Raap
  • Chemistry
    The Journal of antibiotics
  • 1971
^-Amino-4-isothiazolylacetic acid has been prepared by reaction of a-bromo-4-isothiazalylacetic acid with ammonium hydroxide and by catalytic hydrogenation of ^-azido-4-isothiazolylacetic acid. The
Molecular Cloning of the Actinomycin Synthetase Gene Cluster from Streptomyces chrysomallus and Functional Heterologous Expression of the Gene Encoding Actinomycin Synthetase II
Cloned genes of ACMS I (acmA) and ACMS II (acmB) were found to be closely linked and are arranged in opposite orientations by hybridization screening of a cosmid library of Streptomyces chrysomallus DNA with synthetic oligonucleotides derived from peptide sequences of the two enzymes.
abaA, a new pleiotropic regulatory locus for antibiotic production in Streptomyces coelicolor
Subcloning experiments revealed that ORFB together with 137 bp downstream of it is responsible for antibiotic overproduction in S. lividans, and abaA constitutes a new locus which, like the afs and abs genes previously described, pleiotropically regulates antibiotic production.
Stoffwechselprodukte von Actinomyceten. 3. Mitteilung. Nonactin
Aus Kulturfiltrat und Mycel eines Streptomyces viridochromogenes oder Streptomyces olivochromogenes nahestehenden Streptomyceten wurde neben Actidion eine neutrale, farblose, kristalline Verbindung
Pleiotropic effects of cAMP on germination, antibiotic biosynthesis and morphological development in Streptomyces coelicolor
In wild‐type Streptomyces coelicolor MT1110 cultures, cyclic adenosine 3′,5′ monophosphate (cAMP) was synthesized throughout the developmental programme with peaks of accumulation both during germination and later when aerial mycelium and actinorhodin were being produced, suggesting it may serve as a diffusible signalling molecule to co‐ordinate antibiotic biosynthesis.