Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers.

@article{Luu2003DevelopmentOA,
  title={Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers.},
  author={Y K Luu and K Kim and Benjamin S Hsiao and Benjamin Chu and Michael Hadjiargyrou},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2003},
  volume={89 2},
  pages={341-53}
}
The present work utilizes electrospinning to fabricate synthetic polymer/DNA composite scaffolds for therapeutic application in gene delivery for tissue engineering. The scaffolds are non-woven, nano-fibered, membranous structures composed predominantly of poly(lactide-co-glycolide) (PLGA) random copolymer and a poly(D,L-lactide)-poly(ethylene glycol) (PLA-PEG) block copolymer. Release of plasmid DNA from the scaffolds was sustained over a 20-day study period, with maximum release occurring at… CONTINUE READING

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