Development of a multi-target peptide for potentiating chemotherapy by modulating tumor microenvironment.

@article{Song2016DevelopmentOA,
  title={Development of a multi-target peptide for potentiating chemotherapy by modulating tumor microenvironment.},
  author={Xu Chung Song and Zhuoya Wan and Tijia Chen and Yao Fu and Kejun Jiang and Xiaoli Yi and Huan Ke and Jianxia Dong and Liuqing Yang and Lin Li and Xun Sun and Tao Gong and Zhirong Zhang},
  journal={Biomaterials},
  year={2016},
  volume={108},
  pages={
          44-56
        }
}
Finding effective cures against aggressive malignancy remains a major challenge in cancer chemotherapy. Here, we report a "tadpole"-like peptide by covalently conjugating the alanine-alanine-asparagine "tail" residual to the cyclic tumor homing peptide iRGD (CCRGDKGPDC) to afford nRGD, which significantly enhanced tumoricidal effects of doxorubicin, by either co-administered as a physical mixture or as a targeting ligand covalently conjugated to the liposomal carrier. Given twice at an… CONTINUE READING
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