Development of a monoclonal antibody specific to the endonuclease domain of the human LINE-1 ORF2 protein

@inproceedings{Sokolowski2014DevelopmentOA,
  title={Development of a monoclonal antibody specific to the endonuclease domain of the human LINE-1 ORF2 protein},
  author={Mark Sokolowski and Cecily B. DeFreece and Geraldine Servant and Kristine J. Kines and Dawn Deharo and Victoria P. Belancio},
  booktitle={Mobile DNA},
  year={2014}
}
BackgroundLINE-1 (L1) retrotransposons are common occupants of mammalian genomes representing about a fifth of the genetic content. Ongoing L1 retrotransposition in the germ line and somatic tissues has contributed to structural genomic variations and disease-causing mutations in the human genome. L1 mobilization relies on the function of two, self-encoded proteins, ORF1 and ORF2. The ORF2 protein contains two characterized domains: endonuclease and reverse transcriptase.ResultsUsing a… CONTINUE READING

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