Development of a model system to analyze chondrogenic differentiation of mesenchymal stem cells.

@article{Ruedel2013DevelopmentOA,
  title={Development of a model system to analyze chondrogenic differentiation of mesenchymal stem cells.},
  author={Anke Ruedel and Simone Hofmeister and A. Bosserhoff},
  journal={International journal of clinical and experimental pathology},
  year={2013},
  volume={6 12},
  pages={
          3042-8
        }
}
High-density cell culture is widely used for the analysis of cartilage development of human mesenchymal stem cells (HMSCs) in vitro. Several cell culture systems, as micromass, pellet culture and alginate culture, are applied by groups in the field to induce chondrogenic differentiation of HMSCs. A draw back of all model systems is the high amount of cells necessary for the experiments. Further, handling of large experimental approaches is difficult due to culturing e.g. in 15 ml tubes… CONTINUE READING

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