Development of a model for marburgvirus based on severe-combined immunodeficiency mice

@article{Warfield2007DevelopmentOA,
  title={Development of a model for marburgvirus based on severe-combined immunodeficiency mice},
  author={Kelly Lyn Warfield and Derron A. Alves and Steven B. Bradfute and Daniel K Reed and Sean A. Vantongeren and Warren Vincent Kalina and Gene Garrard Olinger and Sina Bavari},
  journal={Virology Journal},
  year={2007},
  volume={4},
  pages={108 - 108}
}
The filoviruses, Ebola (EBOV) and Marburg (MARV), cause a lethal hemorrhagic fever. Human isolates of MARV are not lethal to immmunocompetent adult mice and, to date, there are no reports of a mouse-adapted MARV model. Previously, a uniformly lethal EBOV-Zaire mouse-adapted virus was developed by performing 9 sequential passages in progressively older mice (suckling to adult). Evaluation of this model identified many similarities between infection in mice and nonhuman primates, including viral… CONTINUE READING