Development of a mathematical model for evaluating the dynamics of normal and apoptotic Chinese hamster ovary cells.

@article{Naderi2011DevelopmentOA,
  title={Development of a mathematical model for evaluating the dynamics of normal and apoptotic Chinese hamster ovary cells.},
  author={Saeideh Naderi and Mukesh N. Meshram and Catherine Wei and Brendan J. McConkey and Brian Ingalls and Hector M. Budman and Jeno M. Scharer},
  journal={Biotechnology progress},
  year={2011},
  volume={27 5},
  pages={1197-205}
}
A metabolic flux based methodology was developed for modeling the metabolism of a Chinese hamster ovary cell line. The elimination of insignificant fluxes resulted in a simplified metabolic network which was the basis for modeling the significant metabolites. Employing kinetic rate expressions for growing and non-growing subpopulations, a logistic model was developed for cell growth and dynamic models were formulated to describe culture composition and monoclonal antibody (MAb) secretion. The… CONTINUE READING

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