Development of a live and highly attenuated Listeria monocytogenes-based vaccine for the treatment of Her2/neu-overexpressing cancers in human

@article{Shahabi2011DevelopmentOA,
  title={Development of a live and highly attenuated Listeria monocytogenes-based vaccine for the treatment of Her2/neu-overexpressing cancers in human},
  author={Vafa Shahabi and Matthew M. Seavey and Paulo Cesar Maciag and Stacy Rivera and Anu Wallecha},
  journal={Cancer Gene Therapy},
  year={2011},
  volume={18},
  pages={53-62}
}
A chimeric human Her2/neu gene (ChHer2) harboring most of the known major histocompatibility complex class I epitopes of the HER2/neu oncogene was expressed as a fusion protein to a non-hemolytic fragment of listeriolysin O (LLO), by the highly attenuated Listeria vector LmddA, which lacks antibiotic selection markers and the ability to spread from cell-to… CONTINUE READING