Development of a liquid chromatography-multiple reaction monitoring procedure for concurrent verification of exposure to different forms of mustard agents.

@article{Yeo2008DevelopmentOA,
  title={Development of a liquid chromatography-multiple reaction monitoring procedure for concurrent verification of exposure to different forms of mustard agents.},
  author={Thong-Hiang Yeo and Mer-Lin Ho and W. Tim Loke},
  journal={Journal of analytical toxicology},
  year={2008},
  volume={32 1},
  pages={51-6}
}
A novel liquid chromatography-multiple reaction monitoring (LC-MRM) procedure has been developed for retrospective diagnosis of exposure to different forms of mustard agents. This concise method is able to validate prior exposure to nitrogen mustards (HN-1, HN-2, and HN-3) or sulfur mustard (HD) in a single run, which significantly reduces analysis time compared to separate runs to screen for different mustards' biomarkers based on tandem mass spectrometry. Belonging to one of the more toxic… CONTINUE READING

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