Development of a liquid chromatographic/tandem mass spectrometric assay for a new endothelin receptor antagonist, and its application to dog plasma samples generated after simultaneous i.v. and p.o. administration of the unlabeled and deuterium-labeled forms of this antagonist.

Abstract

An assay was developed and applied to determine the bioavailability of a new endothelin receptor antagonist after simultaneous p.o. and i.v. administration of the drug and its stable isotope-labeled analogue. The drug, its main metabolite and the stable isotope-labeled analogues of the drug and the main metabolite were quantified in dog plasma samples using… (More)

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@article{Lausecker2003DevelopmentOA, title={Development of a liquid chromatographic/tandem mass spectrometric assay for a new endothelin receptor antagonist, and its application to dog plasma samples generated after simultaneous i.v. and p.o. administration of the unlabeled and deuterium-labeled forms of this antagonist.}, author={Berthold Lausecker and G. Fischer}, journal={Journal of mass spectrometry : JMS}, year={2003}, volume={38 6}, pages={649-58} }