Development of a large-scale de-identified DNA biobank to enable personalized medicine.

@article{Roden2008DevelopmentOA,
  title={Development of a large-scale de-identified DNA biobank to enable personalized medicine.},
  author={Dan M. Roden and Jill M. Pulley and Melissa A. Basford and Gordon R. Bernard and Ellen Wright Clayton and Jeffrey R. Balser and Daniel R. Masys},
  journal={Clinical pharmacology and therapeutics},
  year={2008},
  volume={84 3},
  pages={
          362-9
        }
}
Our objective was to develop a DNA biobank linked to phenotypic data derived from an electronic medical record (EMR) system. An "opt-out" model was implemented after significant review and revision. The plan included (i) development and maintenance of a de-identified mirror image of the EMR, namely, the "synthetic derivative" (SD) and (ii) DNA extracted from discarded blood samples and linked to the SD. Surveys of patients indicated general acceptance of the concept, with only a minority… CONTINUE READING
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