Development of a kinetic model to describe the effective rate of antibody oxidation by periodate.

@article{Hage1997DevelopmentOA,
  title={Development of a kinetic model to describe the effective rate of antibody oxidation by periodate.},
  author={David S Hage and Caroline A Wolfe and M R Oates},
  journal={Bioconjugate chemistry},
  year={1997},
  volume={8 6},
  pages={914-20}
}
The oxidation of antibody carbohydrate residues by periodate is a common approach used for site-specific antibody modification and immobilization. This study sought to develop a general kinetic model that could be used to describe the effective rate of this oxidation for process control. A detailed analysis of previous data collected for rabbit immunoglobulin G in the presence of excess periodate indicated that the reaction followed a pseudo-first-order mechanism in which two general classes of… CONTINUE READING