Development of a kinetic model for L-lysine biosynthesis in Corynebacterium glutamicum and its application to metabolic control analysis.

@article{Yang1999DevelopmentOA,
  title={Development of a kinetic model for L-lysine biosynthesis in Corynebacterium glutamicum and its application to metabolic control analysis.},
  author={Chen Yang and Q Hua and Kazuyuki Shimizu},
  journal={Journal of bioscience and bioengineering},
  year={1999},
  volume={88 4},
  pages={393-403}
}
A mathematical model describing intracellular lysine synthesis by Corynebacterium glutamicum in batch fermentation was developed. The model is based on material balance equations of the key metabolites, and includes mechanistically based, experimentally matched rate equations for individual enzymes. From the measurements of the levels of intra- and extracellular metabolites during cultivation, the kinetic parameters in the model were identified through the decomposition of the network of… CONTINUE READING