Development of a hypoxia-responsive vector for tumor-specific gene therapy

  title={Development of a hypoxia-responsive vector for tumor-specific gene therapy},
  author={Toru Shibata and Amato J. Giaccia and Janice M. Y. Brown},
  journal={Gene Therapy},
We are developing new gene therapy vectors whose expression is selectively activated by hypoxia, a unique feature of human solid tumors. As vascular endothelial growth factor (VEGF) is upregulated by hypoxia, such regulatory mechanisms would enable us to achieve hypoxia-inducible expression of therapeutic genes. Constructs with five copies of hypoxia-responsive elements (HREs) derived from the 5′-untranslated region (UTR) of the human VEGF showed excellent transcriptional activation at low… CONTINUE READING
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