Development of a hybrid physiologically based pharmacokinetic model with drug-specific scaling factors in rat to improve prediction of human pharmacokinetics.

@article{Sayama2013DevelopmentOA,
  title={Development of a hybrid physiologically based pharmacokinetic model with drug-specific scaling factors in rat to improve prediction of human pharmacokinetics.},
  author={Hiroyuki Sayama and Hiroshi Komura and Motohiro Kogayu and Masahiro Iwaki},
  journal={Journal of pharmaceutical sciences},
  year={2013},
  volume={102 11},
  pages={4193-204}
}
  • Hiroyuki Sayama, Hiroshi Komura, +1 author Masahiro Iwaki
  • Published 2013 in Journal of pharmaceutical sciences
  • DOI:10.1002/jps.23726
Accurate prediction of pharmacokinetics (PK) in humans has been a vital part of drug discovery. The aims of this study are to verify the usefulness of scaling factors for clearance (CL) and apparent volume of distribution at the steady state (Vss ) estimated from the difference between observed and predicted PK profiles in rats for human PK prediction, and… CONTINUE READING