Development of a highly specific and sensitive molecular probe for detection of cutaneous lymphoma.

@article{Volkenandt1991DevelopmentOA,
  title={Development of a highly specific and sensitive molecular probe for detection of cutaneous lymphoma.},
  author={Matthias Volkenandt and Hans Peter Soyer and Helmut Kerl and J R Bertino},
  journal={The Journal of investigative dermatology},
  year={1991},
  volume={97 1},
  pages={137-40}
}
Using DNA from formalin-fixed paraffin-embedded tissue of a patient with mycosis fungoides, a highly specific and sensitive molecular probe for the malignant lymphoid cells of this patient was developed. Polymerase chain reaction (PCR) was used to selectively amplify the region of the rearrangement of TCR-gamma genes. Randomly inserted nucleotides between… CONTINUE READING