Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.

@article{Mukhopadhyay2010DevelopmentOA,
  title={Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.},
  author={Asima Mukhopadhyay and Ahmed Elattar and Aiste Cerbinskaite and Sarah J Wilkinson and Yvette Drew and Suzanne Kyle and Gerrit Los and Zdenek Hostomsky and Richard J Edmondson and Nicola J Curtin},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 8},
  pages={2344-51}
}
PURPOSE Poly(ADP-ribose) polymerase (PARP) inhibitors selectively target homologous recombination (HR)-defective cells and show good clinical activity in hereditary breast and ovarian cancer associated with BRCA1 or BRCA2 mutations. A high proportion (up to 50%) of sporadic epithelial ovarian cancers (EOC) could be deficient in HR due to genetic or epigenetic inactivation of BRCA1/BRCA2 or other HR genes. Therefore, there is a potential for extending the use of PARP inhibitors to these patients… CONTINUE READING

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View 7 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Inhibition of poly(ADP-ribose) polymerase in BRCA mutation carriers.

The New England journal of medicine • 2009
View 1 Excerpt

γH2AX and cancer

Nature Reviews Cancer • 2008
View 1 Excerpt

Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2007

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