Development of a formal catalytic asymmetric [4+2] addition of ethyl-2,3-butadienoate with acyclic enones.

@article{Ashtekar2011DevelopmentOA,
  title={Development of a formal catalytic asymmetric [4+2] addition of ethyl-2,3-butadienoate with acyclic enones.},
  author={Kumar Dilip Ashtekar and Richard J. Staples and Babak Borhan},
  journal={Organic letters},
  year={2011},
  volume={13 21},
  pages={5732-5}
}
Allene esters are unique not only as excellent electrophiles but also because of their ability for subsequent reactivity after the initial nucleophilic attack. A mechanistically inspired cyclization using ethyl-2,3-butadienoate and acyclic enones to provide dihydropyrans in excellent yields and enantioselectivity under solvent-free conditions at room… CONTINUE READING
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