Development of a dynamic multiple reaction monitoring method for determination of digoxin and six active components of Ginkgo biloba leaf extract in rat plasma.

@article{Rao2014DevelopmentOA,
  title={Development of a dynamic multiple reaction monitoring method for determination of digoxin and six active components of Ginkgo biloba leaf extract in rat plasma.},
  author={Zhi Rao and Hongyan Qin and Yuhui Wei and Yongqin Zhou and Guoqiang Zhang and Facong Zhang and Yun-yun Shao and Jing Huang and Xinan Wu},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2014},
  volume={959},
  pages={
          27-35
        }
}
  • Zhi Rao, Hongyan Qin, +6 authors Xinan Wu
  • Published 2014
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • A new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method by using dynamic multiple reaction monitoring (DMRM) has been developed and validated for the simultaneous determination of digoxin (DGX) and six main components of Ginkgo biloba leaf extract (GBE) in rat plasma. Comparing with the conventional multiple reaction monitoring (MRM), DMRM dramatically decreases the number of concurrent MRM transitions, and significantly extended the dwell time, which provided much higher… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 34 REFERENCES

    Simultaneous determination and pharmacokinetic study of six flavonoids from Fructus Sophorae extract in rat plasma by LC-MS/MS.