Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies. Development of a relational database.

@article{Gerner2000DevelopmentOA,
  title={Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies. Development of a relational database.},
  author={Ingrid Gerner and G Graetschel and Jennifer Kahl and Eva Schlede},
  journal={Alternatives to laboratory animals : ATLA},
  year={2000},
  volume={28 1},
  pages={11-28}
}
For new chemical substances that are notified within the European Union, data sets have to be submitted to the National Competent Authorities. The data submitted have to demonstrate the physicochemical and toxic properties of the new chemical, such as solubility, partition coefficients and spectra, as well as acute toxic properties and the potential to cause local irritant or corrosive effects. In order to minimise testing for notification purposes (for example, animal testing), it is necessary… CONTINUE READING
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