Development of a decision-making biomarker for CRTH2 antagonism in clinical studies

  title={Development of a decision-making biomarker for CRTH2 antagonism in clinical studies},
  author={D. Strasser and H. Farine and M. Holdener and J. Zisowsky and Ren{\'e} Roscher and Julie Hoerner and M. G{\'e}hin and P. Sidharta and J. Dingemanse and P. Groenen},
  journal={New Horizons in Translational Medicine},
  • D. Strasser, H. Farine, +7 authors P. Groenen
  • Published 2015
  • Biology
  • New Horizons in Translational Medicine
  • Abstract Biomarkers have shown to improve success rates in the development of novel drugs, providing essential information in the early phases of clinical development for decision-making. Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is pursued as a drug target for a number of inflammatory diseases. CRTH2 antagonists block the activation and migration of key inflammatory cells such as eosinophils, basophils, and Th2 cells. The mechanism of action of CRTH2… CONTINUE READING
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