Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides.

@article{LackmanSmith2008DevelopmentOA,
  title={Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides.},
  author={Carol S Lackman-Smith and Clay Osterling and Katherine Luckenbaugh and Marie Mankowski and Beth A. Snyder and Gareth Lewis and Jeremy R. A. Paull and Albert Profy and Roger G. Ptak and Robert W. Buckheit and Karen M. Watson and James E Cummins and Brigitte E Sanders-Beer},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 5},
  pages={1768-81}
}
Topical microbicides are self-administered, prophylactic products for protection against sexually transmitted pathogens. A large number of compounds with known anti-human immunodeficiency virus type 1 (HIV-1) inhibitory activity have been proposed as candidate topical microbicides. To identify potential leads, an in vitro screening algorithm was developed to evaluate candidate microbicides in assays that assess inhibition of cell-associated and cell-free HIV-1 transmission, entry, and fusion… CONTINUE READING

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