Development of a cocktail of recombinant-expressed human rabies virus-neutralizing monoclonal antibodies for postexposure prophylaxis of rabies.

@article{Prosniak2003DevelopmentOA,
  title={Development of a cocktail of recombinant-expressed human rabies virus-neutralizing monoclonal antibodies for postexposure prophylaxis of rabies.},
  author={Mikhail Prosniak and Milosz Faber and Cathleen Alma Hanlon and Charles E. Rupprecht and D Craig Hooper and Bernhard Dietzschold},
  journal={The Journal of infectious diseases},
  year={2003},
  volume={188 1},
  pages={
          53-6
        }
}
To provide a cost-effective and safe replacement for human rabies immunoglobulin (HRIG), we used DNA recombinant technology to express 3 human rabies virus-neutralizing human monoclonal antibodies (huMAbs) in a rhabdovirus vector (RhV). Infection of either baby hamster kidney cells or CHO cells, with the resulting RhV-huMAb recombinant viruses, yielded high-level production (< or =40 micro g/mL/48 h) of RhV recombinant-expressed huMAbs (rhuMAbs) that differ in both isotype and epitope… CONTINUE READING

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