Development of a chimeric replicon system for phenotypic analysis of NS3 protease sequences from HCV clinical isolates.

Abstract

BACKGROUND To support clinical development of HCV non-structural protein (NS) 3 protease inhibitors (PIs), phenotypic monitoring of patient isolates is a prerequisite for understanding the emergence of resistance. HCV isolates typically fail to replicate in cell culture, necessitating the use of alternative phenotyping methods. METHODS An NS3 protease… (More)
DOI: 10.3851/IMP1825

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