Development of a cell-based assay for the detection of anti-aquaporin 1 antibodies in neuromyelitis optica spectrum disorders.

@article{Long2014DevelopmentOA,
  title={Development of a cell-based assay for the detection of anti-aquaporin 1 antibodies in neuromyelitis optica spectrum disorders.},
  author={Youming Long and Yangbo Zheng and Fulan Shan and Mengyu Chen and Yongxiang Fan and Bin Zhang and Chengyong Gao and Qingchun Gao and Ning Yang},
  journal={Journal of neuroimmunology},
  year={2014},
  volume={273 1-2},
  pages={103-10}
}
OBJECTIVE To develop a cell-based assay (CBA) to detect aquaporin 1 (AQP1) antibodies and determine sensitivity/specificity in patients with neuromyelitis optica (NMO) spectrum disorders. METHODS A HEK-293T transfected cell model expressing AQP1 was established and detected to be serum AQP1 antibodies. RESULTS AQP1 antibodies were present in 73/98 (74.5%) AQP4 antibody-positive patients. Some AQP4 antibody-negative patients were also AQP1 antibody-positive. Test sensitivity was 74.5% in 98… CONTINUE READING

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