Development of a calcium-chelating hydrogel for treatment of superficial burns and scalds.

Abstract

AIMS Superficial burns and scalds are usually managed conservatively with traditional dressings. Failure to heal within 3 weeks leads to their management by skin grafting. Our aim was to develop a biomaterial to actively promote keratinocyte migration in superficial burns by modulating local cation concentrations to accelerate keratinocyte migration and deter wounds from contracting, thus potentially reducing the number of such wounds requiring grafting. MATERIALS & METHODS We investigated polymeric hydrogels for their Ca(2+) chelating properties and enhancement of keratinocyte migration in human tissue-engineered skin models. RESULTS Dimethylaminoethyl methacrylate:methacrylic acid hydrogel coupled with elevated [Mg(2+)] reduced media [Ca(2+)], potentiating keratinocyte migration in tissue-engineered skin models, it also significantly reduced wound model contraction. CONCLUSION Dimethylaminoethyl methacrylate:methacrylic acid hydrogels could promote wound healing and reduce wound contraction, a significant complication in burn wound healing.

DOI: 10.2217/rme.09.67

Cite this paper

@article{Bullock2010DevelopmentOA, title={Development of a calcium-chelating hydrogel for treatment of superficial burns and scalds.}, author={Anthony J. Bullock and Paul Pickavance and David B Haddow and Stephen Rimmer and S Macneil}, journal={Regenerative medicine}, year={2010}, volume={5 1}, pages={55-64} }