Development of a bioactive porous collagen/β-tricalcium phosphate bone graft assisting rapid vascularization for bone tissue engineering applications.

@article{Baheiraei2018DevelopmentOA,
  title={Development of a bioactive porous collagen/β-tricalcium phosphate bone graft assisting rapid vascularization for bone tissue engineering applications.},
  author={Nafiseh Baheiraei and Mahsan Nourani and Seyed Mohammad Javad Mortazavi and Mansoureh Movahedin and Hossein Eyni and Farnoosh Bagheri and Mohammad Hadi Norahan},
  journal={Journal of biomedical materials research. Part A},
  year={2018},
  volume={106 1},
  pages={
          73-85
        }
}
We developed collagen (COL) and collagen/beta tricalcium phosphate (COL/β-TCP) scaffolds with a β-TCP/collagen weight ratio of 4 by freeze-drying. Mouse bone marrow-derived mesenchymal stem cells (BMMSCs) were cultured on these scaffolds for 14 days. Samples were characterized by physicochemical analyses and their biological properties such as cell viability and alkaline phosphatase (ALP) activity was, also, examined. Additionally, the vascularization potential of the prepared scaffolds was… CONTINUE READING
BETA