Development of a Two-part Strategy to Identify a Therapeutic Human Bispecific Antibody That Inhibits IgE Receptor Signaling*

@inproceedings{Jackman2010DevelopmentOA,
  title={Development of a Two-part Strategy to Identify a Therapeutic Human Bispecific Antibody That Inhibits IgE Receptor Signaling*},
  author={J. Jackman and Yongmei Chen and Arthur J. Huang and Barbara Moffat and Justin M Scheer and Steven R. Leong and Wyne P Lee and Juan Zhang and Navneet Sharma and Yanmei Lu and Suhasini Iyer and Robert L. Shields and Nancy Y. Chiang and Michele C. Bauer and Diana Wadley and Merone Roose-Girma and Richard Vandlen and Daniel G. Yansura and Yan Wu and Lawren C. Wu},
  booktitle={The Journal of biological chemistry},
  year={2010}
}
The development of bispecific antibodies as therapeutic agents for human diseases has great clinical potential, but broad application has been hindered by the difficulty of identifying bispecific antibody formats that exhibit favorable pharmacokinetic properties and ease of large-scale manufacturing. Previously, the development of an antibody technology utilizing heavy chain knobs-into-holes mutations and a single common light chain enabled the small-scale generation of human full-length… CONTINUE READING

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